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KMID : 0613820170270080896
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Journal of Life Science
2017 Volume.27 No. 8 p.896 ~ p.901
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Protective Effects of Succinic Acid of Succiniter against Liver Toxicity
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Kim Hong-Bi
Ha Bae-Jin
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Abstract
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This study was performed to investigate the protective effects of succinic acid of Succiniter against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. After an adaptation period of one week, Sprague-Dawley rats were administered succinic acid of Succiniter at 200 mg/kg every day for 21 days. Then CCl4 (3.3 ml/kg) was intraperitoneally injected into rats of the other groups except the normal group, five hours after the last treatment of succinic acid of Succiniter on day 21. The succinic acid-treated group showed 93.20% and 88.76% of inhibitory effects in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, respectively, compared with the CCl4-treated group. The succinic acid-treated group showed inhibition of malonedialdehyde (MDA) by 85.17% compared with the CCl4-treated group. The succinic acid-treated group in liver homogenate promoted effects of 38.65% and 47.99% in superoxide dismutase (SOD) and catalase (CAT), respectively, compared with the CCl4-treated group. In conclusion, the AST and ALT activities of the succinic acid-treated group were both decreased compared with the CCl4-treated group. The MDA level of the succinic acid-treated group was decreased compared with the CCl4-treated group. However, the SOD and CAT levels of the succinic acid-treated group in liver homogenate were both increased compared with the CCl4-treated group. Also, histological examinations showed that the liver cell necrosis and centrilobular congestion aggregation induced by CCl4 were clearly eliminated by treatment with succinic acid of Succiniter. These results suggest that succinic acid of Succiniter has a protective effect against liver damage and could be used in the development of the appropriate drug.
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KEYWORD
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Carbon tetrachloride, hepatotoxicity, malonedialdehyde, succinic acid of Succiniter, superoxide dismutase
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